[HTML][HTML] PD-L1 testing for lung cancer in 2019: perspective from the IASLC pathology committee

S Lantuejoul, M Sound-Tsao, WA Cooper… - Journal of Thoracic …, 2020 - Elsevier
The recent development of immune checkpoint inhibitors (ICIs) has led to promising
advances in the treatment of patients with NSCLC and SCLC with advanced or metastatic …

Deep learning for lung cancer diagnosis, prognosis and prediction using histological and cytological images: a systematic review

A Davri, E Birbas, T Kanavos, G Ntritsos, N Giannakeas… - Cancers, 2023 - mdpi.com
Simple Summary Lung cancer is one of the most common and deadly malignancies
worldwide. Microscopic examination of histological and cytological lung specimens can be a …

Multiplex immunohistochemistry accurately defines the immune context of metastatic melanoma

H Halse, AJ Colebatch, P Petrone, MA Henderson… - Scientific reports, 2018 - nature.com
A prospective study explored the heterogeneous nature of metastatic melanoma using
Multiplex immunohistochemistry (IHC) and flow cytometry (FACS). Multiplex IHC data …

High PD-L1 expression is associated with therapeutic response to pembrolizumab in patients with advanced biliary tract cancer

S Ahn, J Lee, DW Shin, J Kim, JH Hwang - Scientific reports, 2020 - nature.com
Pembrolizumab appears promising for patients with programmed cell death ligand-1 (PD-
L1)-positive solid tumors. However, data on immunotherapy for biliary tract cancers (BTC) …

Analytical concordance of PD-L1 assays utilizing antibodies from FDA-approved diagnostics in advanced cancers: a systematic literature review

EA Prince, JK Sanzari, D Pandya, D Huron… - JCO Precision …, 2021 - ascopubs.org
PURPOSE Four programmed death ligand 1 (PD-L1) immunohistochemistry assays (28-8,
22C3, SP263, and SP142) have been approved for use by the US Food and Drug …

Deep semi supervised generative learning for automated tumor proportion scoring on NSCLC tissue needle biopsies

A Kapil, A Meier, A Zuraw, KE Steele, MC Rebelatto… - Scientific reports, 2018 - nature.com
The level of PD-L1 expression in immunohistochemistry (IHC) assays is a key biomarker for
the identification of Non-Small-Cell-Lung-Cancer (NSCLC) patients that may respond to anti …

[HTML][HTML] PD-L1 testing in non-small cell lung cancer: past, present, and future

H Kim, JH Chung - Journal of pathology and translational medicine, 2019 - ncbi.nlm.nih.gov
Blockade of the programmed cell death-1 (PD-1) axis has already been established as an
effective treatment of non-small cell lung cancer. Immunohistochemistry (IHC) for …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lung cancer and mesothelioma

R Govindan, C Aggarwal, SJ Antonia… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Immunotherapy has transformed lung cancer care in recent years. In addition to providing
durable responses and prolonged survival outcomes for a subset of patients with heavily …

Multiplex immunohistochemistry/immunofluorescence (mIHC/IF) for PD-L1 testing in triple-negative breast cancer: a translational assay compared with conventional …

J Yeong, T Tan, ZL Chow, Q Cheng, B Lee… - Journal of Clinical …, 2020 - jcp.bmj.com
Background Programmed death-ligand 1 (PD-L1) monoclonal antibody therapy has recently
gained approval for treating metastatic triple-negative breast cancer (TNBC)-, in particular in …

Domain adaptation-based deep learning for automated tumor cell (TC) scoring and survival analysis on PD-L1 stained tissue images

A Kapil, A Meier, K Steele, M Rebelatto… - … on Medical Imaging, 2021 - ieeexplore.ieee.org
We report the ability of two deep learning-based decision systems to stratify non-small cell
lung cancer (NSCLC) patients treated with checkpoint inhibitor therapy into two distinct …