Catecholaminergic transmission plays an essential role in both physiological and
pathological cognitive functions. Plastic changes subserving learning and memory …

The pathogenesis of Alzheimer's disease (AD) is not fully understood. Here we summarize
current knowledge on the involvement of the serotonergic, noradrenergic, dopaminergic …

Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on
patients and their relatives. These symptoms are associated with cortical hypodopamynergia …

Introduction Certain genes increase the risk of age-related neurological dysfunction and/or
disease. For instance, ApoE is a well-known gene carrying risk for Alzheimer's disease …

In this narrative review, we examine biological processes linking psychological stress and
cognition, with a focus on how psychological stress can activate multiple neurobiological …

Different polymorphisms of the catechol-O-methyltransferase (COMT) gene affect the COMT
enzyme activity. The COMT enzyme plays a major role in the pathophysiology of various …

Introduction. Genetic factors play an important role in Parkinson's disease (PD) risk.
However, the genetic contribution to progression in Chinese PD patients has rarely been …

Dementia is a multifactorial disease in which environmental, lifestyle, and genetic factors
intervene. Population studies have been used in looking for the susceptibility genes for this …

vi such as ion channels, membrane transporters, receptors, and enzymes are playing
increasingly essential roles in drug design and pharmacogenomics studies (see Chapters 6 …

There are many trillions of bacteria in the gastrointestinal microbiome (GM). Their ecological
dysregulation can contribute to the development of certain neurodegenerative diseases …