Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers

N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Trends in the development of miRNA bioinformatics tools

L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via
recognition of cognate sequences and interference of transcriptional, translational or …

ReMap 2022: a database of Human, Mouse, Drosophila and Arabidopsis regulatory regions from an integrative analysis of DNA-binding sequencing experiments

F Hammal, P De Langen, A Bergon… - Nucleic acids …, 2022 - academic.oup.com
Abstract ReMap (https://remap. univ-amu. fr) aims to provide manually curated, high-quality
catalogs of regulatory regions resulting from a large-scale integrative analysis of DNA …

Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance

Y Liu, G Liang, H Xu, W Dong, Z Dong, Z Qiu, Z Zhang… - Cell metabolism, 2021 - cell.com
The ever-increasing understanding of the complexity of factors and regulatory layers that
contribute to immune evasion facilitates the development of immunotherapies. However, the …

Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis

R Zheng, C Wan, S Mei, Q Qin, Q Wu… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Cistrome Data Browser (DB) is a resource of human and mouse cis-regulatory
information derived from ChIP-seq, DNase-seq and ATAC-seq chromatin profiling assays …

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

H Huang, H Weng, K Zhou, T Wu, BS Zhao, M Sun… - Nature, 2019 - nature.com
DNA and histone modifications have notable effects on gene expression. Being the most
prevalent internal modification in mRNA, the N 6-methyladenosine (m6A) mRNA …

hTFtarget: a comprehensive database for regulations of human transcription factors and their targets

Q Zhang, W Liu, HM Zhang, GY Xie… - Genomics …, 2020 - academic.oup.com
Transcription factors (TFs) as key regulators play crucial roles in biological processes. The
identification of TF–target regulatory relationships is a key step for revealing functions of TFs …

PlantPAN3. 0: a new and updated resource for reconstructing transcriptional regulatory networks from ChIP-seq experiments in plants

CN Chow, TY Lee, YC Hung, GZ Li… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Plant Promoter Analysis Navigator (PlantPAN; http://PlantPAN. itps. ncku. edu.
tw/) is an effective resource for predicting regulatory elements and reconstructing …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

N6-methyladenosine regulates glycolysis of cancer cells through PDK4

Z Li, Y Peng, J Li, Z Chen, F Chen, J Tu, S Lin… - Nature …, 2020 - nature.com
Studies on biological functions of N 6-methyladenosine (m6A) modification in mRNA have
sprung up in recent years. We find m6A can positively regulate the glycolysis of cancer cells …