Soft tissue tumors are a relatively rare and diagnostically challenging group of neoplasms
that can have varying lines of differentiation. Accurate diagnosis is important for appropriate …

The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and
Bone was published in early 2020. The revisions reflect a consensus among an …

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …

Summary Background Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder,
predisposing development of benign and malignant tumours. Given the oncogenic potential …

Tumors characterized by co‐expression of S100 and CD34, in the absence of SOX10,
remain difficult to classify. Triggered by a few index cases with monomorphic …

The wide variety of clinical manifestations of the genetic syndrome neurofibromatosis type 1
(NF1) are driven by overactivation of the RAS pathway. Mitogen-activated protein kinase …

Neoplasms of the peripheral nervous system represent a heterogenous group with a wide
spectrum of morphological features and biological potential. They range from benign and …

Undifferentiated pleomorphic sarcomas, myxofibrosarcomas, and malignant peripheral
nerve sheath tumors are characterized by complex genomic characteristics and aggressive …

To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis
1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas …

Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma,
occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and …