A molecular view of kinetochore assembly and function
A Musacchio, A Desai - Biology, 2017 - mdpi.com
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …
The four causes: the functional architecture of centromeres and kinetochores
AD McAinsh, AL Marston - Annual review of genetics, 2022 - annualreviews.org
Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
Structure of the human outer kinetochore KMN network complex
S Yatskevich, J Yang, D Bellini, Z Zhang… - Nature structural & …, 2024 - nature.com
Faithful chromosome segregation requires robust, load-bearing attachments of
chromosomes to the mitotic spindle, a function accomplished by large macromolecular …
chromosomes to the mitotic spindle, a function accomplished by large macromolecular …
The kinetochore
IM Cheeseman - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …
cells. The central player in this process is the macromolecular kinetochore structure, which …
Molecular genetics of human primary microcephaly: an overview
Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder that
is characterised by microcephaly present at birth and non-progressive mental retardation …
is characterised by microcephaly present at birth and non-progressive mental retardation …
BUB1 and CENP-U, primed by CDK1, are the main PLK1 kinetochore receptors in mitosis
Reflecting its pleiotropic functions, Polo-like kinase 1 (PLK1) localizes to various sub-cellular
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …
Structure of the MIS12 complex and molecular basis of its interaction with CENP-C at human kinetochores
A Petrovic, J Keller, Y Liu, K Overlack, J John… - Cell, 2016 - cell.com
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle
microtubules to promote chromosome segregation. The 10-subunit KMN assembly …
microtubules to promote chromosome segregation. The 10-subunit KMN assembly …
Higher-order protein assembly controls kinetochore formation
GB Sissoko, EV Tarasovetc, O Marescal… - Nature cell …, 2024 - nature.com
To faithfully segregate chromosomes during vertebrate mitosis, kinetochore–microtubule
interactions must be restricted to a single site on each chromosome. Prior work on pair-wise …
interactions must be restricted to a single site on each chromosome. Prior work on pair-wise …
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore
E Screpanti, A De Antoni, GM Alushin, A Petrovic… - Current Biology, 2011 - cell.com
Kinetochores are proteinaceous scaffolds implicated in the formation of load-bearing
attachments of chromosomes to microtubules during mitosis. Kinetochores contain distinct …
attachments of chromosomes to microtubules during mitosis. Kinetochores contain distinct …