Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Tumors are populated by antigen-presenting cells (APCs) including macrophage subsets
with distinct origins and functions. Here, we examined how cancer impacts mononuclear …

Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …

Nitric oxide and its production by iNOS is an established mechanism critical to tumor
promotion or suppression. Macrophages have important roles in immunity, development …

Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy.
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear …

Tumor associated macrophages (TAMs) are the most frequent immune cells within tumor
microenvironment (TME). There is growing evidence that TAMs are involved in tumor …