The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …

GH/insulin/IGF-1 signaling is a vital pathway eg in the regulation of protein synthesis and
glucose metabolism. However, mouse dwarf strains which exhibit reduced GH secretion and …

Hyaluronan (HA) is a large nonsulfated glycosaminoglycan and an important regulator of
angiogenesis, in particular, the growth and migration of vascular endothelial cells. We have …

Acromegaly is characterized by sustained elevation of circulating growth hormone (GH) and
insulin-like growth factor I (IGF-I), and is clearly associated with increased morbidity and …

While growth hormone (GH) is classically defined as a peptide hormone, recent evidence
supports a role for GH acting as a cytokine in the immune system under conditions of stress …

Myc regulates to some degree every major process in the cell. Proliferation, growth,
differentiation, apoptosis, and metabolism are all under Myc control. In turn, these processes …

Growth hormone receptor (GHR) has been demonstrated to be nuclear localized both in vivo
and in vitro, but the significance of this observation has remained elusive. Here we show that …

Increasing evidence has placed hormones and neuropeptides among potent
immunomodulators, in both health and disease. Herein, we focus on the effects of growth …

The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis regulates cardiac growth,
stimulates myocardial contractility and influences the vascular system. The GH/IGF-1 axis …

Growth hormone (GH) is a major growth-promoting and metabolic regulatory hormone.
Interaction of GH with its cell surface GH receptor (GHR), by virtue of receptor dimerization …