Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Background Calcium ions are involved in several human cellular processes including
corticogenesis, transcription, and synaptogenesis. Nevertheless, the relationship between …

Compromised placental function or premature loss has been linked to diverse
neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a …

Loss-of-function mutations in the gene encoding the postsynaptic scaffolding protein
SHANK2 are a highly penetrant cause of autism spectrum disorders (ASD) involving …

Our motor outputs are constantly re-calibrated to adapt to systematic perturbations. This
motor adaptation is thought to depend on the ability to form a memory of a systematic …

The coordination of movement across the body is a fundamental, yet poorly understood
aspect of motor control. Mutant mice with cerebellar circuit defects exhibit characteristic …

Stable and efficient locomotion requires the precise coordination of movement across the
limbs and body. Learned changes in interlimb coordination can be induced by exposure to a …

Lower limb loss is a major insult to the body's nervous and musculoskeletal systems.
Despite technological advances in prosthesis design, artificial limbs are not yet integrated …

For many decades, the predominant view in the cerebellar field has been that the
olivocerebellar system's primary function is to induce plasticity in the cerebellar cortex …

The cerebellum plays a crucial role in the regulation of locomotion, but how movement is
represented at the synaptic level is not known. Here, we use in vivo patch-clamp recordings …