The vast majority of acute heart failure episodes are characterized by increasing symptoms
and signs of congestion with volume overload. The goal of therapy in those patients is the …

Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper
distribution of potassium across the cell membrane is critical for normal cell function. Long …

When challenged by hypertonicity, dehydrated cells must recover their volume to survive.
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …

Consumption of low dietary potassium, common with ultraprocessed foods, activates the
thiazide-sensitive sodium chloride cotransporter (NCC) via the w ith no (K) lysine …

Dietary potassium deficiency, common in modern diets, raises blood pressure and
enhances salt sensitivity. Potassium homeostasis requires a molecular switch in the distal …

Compared with males, females have lower BP before age 60, blunted hypertensive
response to angiotensin II, and a leftward shift in pressure natriuresis. This study tested the …

Total body potassium content and proper distribution of potassium across the cell membrane
is of critical importance for normal cellular function. Potassium homeostasis is maintained by …

Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Hypertension and chronic kidney disease (CKD) are complex traits representing major
global health problems 1, 2. Multiple genome-wide association studies have identified …

The kidney filters vast quantities of Na at the glomerulus but excretes a very small fraction of
this Na in the final urine. Although almost every nephron segment participates in the …