It is now firmly established that the contraction of muscle and many of the movements of
nonmuscle cells result from the interaction of two proteins, actin and myosin. These …

Hypertrophic cardiomyopathy (HCM), a disease characterized by cardiac muscle
hypertrophy and hypercontractility, is the most frequently inherited disorder of the heart …

Relaxation of vertebrate skeletal muscle is thought to occur in the absence of Ca 2+ as a
result of tropomyosin physically blocking the binding of myosin to actin. This steric blocking …

L-------------------------------------------Kathy Ruppel, Ken Niebling and JeffFiner for their help and
comments on the first draft. I am also grateful for discussions with and comments from Dr …

In vitro at low ionic strength (mu= 0.02 M) and 5 degrees C, myosin subfragment-1 shows
significant binding to regulated actin in the presence of ATP, independent of the …

Electron micrographs showing different cross-bridge orientations in different states of muscle
fibres, and X-ray diffraction patterns indicating axial cross-bridge disorder in contracting …

We have used electron paramagnetic resonance (EPR) spectra to study spin labels
selectively and rigidly attached to myosin heads in glycerinated rabbit psoas muscle fibers …

Actin is one of the most widespread proteins in eukaryotic cells. This book and its
companion (" Molecular Interactions of Actin. Actin Structure and Actin-Binding Proteins") …

The super-relaxed state of myosin (SRX), in which the myosin ATPase activity is strongly
inhibited, has been observed in a variety of muscle types. It has been proposed that myosin …

We propose a molecular mechanism of force generation in muscle, based primarily on site-
specific spectroscopic probe studies of myosin heads in contracting muscle fibers and …