Leukotriene D4 role in allergic asthma pathogenesis from cellular and therapeutic perspectives

N Al-Azzam, L Elsalem - Life sciences, 2020 - Elsevier
Asthma is a chronic inflammatory and allergic disease that is mainly characterized by
reversible airway obstruction and bronchial hyperresponsiveness. The incidence of asthma …

Aloperine suppresses allergic airway inflammation through NF-κB, MAPK, and Nrf2/HO-1 signaling pathways in mice

C Wang, YH Choi, Z Xian, M Zheng, H Piao… - International …, 2018 - Elsevier
To explore the effects of aloperine (ALO) on allergic airway inflammation, we investigated
whether its mechanism is related with NF-κB, MAPK, and Nrf2/HO-1 signaling pathways …

Flow-independent nitric oxide parameters in asthma: a systematic review and meta-analysis

T Karvonen, L Lehtimäki - Journal of breath research, 2019 - iopscience.iop.org
Introduction. Fractional exhaled nitric oxide (FE NO) has been proposed as a non-invasive
marker of inflammation in the lungs. Measuring FE NO at several flow rates enables the …

[HTML][HTML] Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

T Xu, X Ge, C Lu, W Dai, H Chen, Z Xiao, L Wu… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Asthma is a type of chronic lung inflammation with restrictions in effective therapy. NF-κB
pathway activation has been suggested to play an important role in the pathogenesis of …

Nitric oxide: The missing factor in COVID-19 severity?

A Nikolaidis, R Kramer, S Ostojic - Medical Sciences, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) is a contagious respiratory and vascular disease that
continues to spread among people around the world, mutating into new strains with …

Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators

JM Chun, AR Lee, HS Kim, AY Lee, GJ Gu… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance The root of Peucedanum japonicum Thunberg is
traditionally used to treat coughs, colds, headache and inflammatory diseases in Korea and …

A comprehensive evaluation of mepolizumab effectiveness in a real-life setting

P Cameli, L Bergantini, M d'Alessandro… - … Archives of Allergy and …, 2020 - karger.com
Abstract Introduction: Interleukin-5 (IL-5) is the principal cytokine regulating eosinophil
growth, differentiation, activation, and expression. It is a specific target of mepolizumab, an …

BALB/c and C57BL/6 mice differ in oxidant and antioxidant responses in innate and adaptive immune cells in an asthma model induced by cockroach allergens

LA Al-Kharashi, SA Alqarni, SF Ahmad… - International …, 2023 - Elsevier
Asthma is a complex and heterogenous disease affected by a multitude of factors. Several
phenotypes of asthma exist which are influenced by various molecular mechanisms that …

Endoplasmic reticulum, Golgi, and lysosomes are disorganized in lung fibroblasts from chronic obstructive pulmonary disease patients

J Weidner, L Jarenbäck, I Åberg… - Physiological …, 2018 - Wiley Online Library
Abstract Chronic Obstructive Pulmonary Disease (COPD) is often caused by smoking and
other stressors. This causes oxidative stress, which induces numerous changes on both the …

Exhaled nitric oxide in pediatric patients with respiratory disease

M Rachel, M Biesiadecki, D Aebisher… - Journal of breath …, 2019 - iopscience.iop.org
Measurement of nitric oxide (NO) levels in exhaled air from the upper and lower airways is
currently used as a non-invasive marker of inflammation in respiratory diseases …