Voltage-gated proton channels (HV) are unique, in part because the ion they conduct is
unique. HV channels are perfectly selective for protons and have a very small unitary …

Voltage-gated potassium channels play a fundamental role in the generation and
propagation of the action potential. The discovery of these channels began with predictions …

Handbook of Ion Channels illustrates the fundamental importance of these membrane
proteins to human health and disease. Renowned researchers from around the world …

We celebrate this year the 50th anniversary of the first electrophysiological recordings of the
gating currents from voltage-dependent ion channels done in 1973. This retrospective tries …

Voltage-gated proton channels are unique ion channels, membrane proteins that allow
protons but no other ions to cross cell membranes. They are found in diverse species, from …

Ca V 1.1 is specifically expressed in skeletal muscle where it functions as voltage sensor of
skeletal muscle excitation-contraction (EC) coupling independently of its functions as L-type …

Excitation-evoked Ca2+ influx is the fastest and most ubiquitous chemical trigger for cellular
processes, including neurotransmitter release, muscle contraction, and gene expression …

hERG potassium channels have a critical role in the normal electrical activity of the heart.
The block of hERG channels can cause the drug-induced form of long QT syndrome, a …

Ions in water are the liquid of life. Life occurs almost entirely in “salt water.” Life began in
salty oceans. Animals kept that salt water within them when they moved out of the ocean to …

Voltage-sensor domains couple membrane potential to conformational changes in voltage-
gated ion channels and phosphatases. Highly coevolved acidic and aromatic side chains …