RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Abstract ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute
lymphoblastic leukemia (ALL). Multiple lines of evidence imply a “two-hit” model for the …

Cancer cells acquire unlimited proliferative capacity by either re-expressing telomerase or
inducing alternative lengthening of telomeres (ALT), which relies on telomere …

Acute lymphoblastic leukemia (ALL) is classified as B‐lineage ALL (B‐ALL) and T‐lineage
ALL (T‐ALL). The incidence of ALL is almost three times higher in white than black children …

B-cell precursor childhood acute lymphoblastic leukemia with ETV6-RUNX1 (TEL-AML1)
fusion has an overall good prognosis, but relapses occur, usually after cessation of …

Abstract The t (12; 21) translocation that generates the ETV6-RUNX1 (TEL-AML1) fusion
gene, is the most common chromosomal rearrangement in childhood cancer and is …

The most frequent chromosomal rearrangement in childhood B-cell acute lymphoblastic
leukemia (B-ALL) is translocation t (12; 21)(p13; q22). It results in the fusion of the ETV6 …

The IKZF 1 gene at 7p12. 2 codes for IKAROS (also termed IKZF 1), an essential
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …

Abstract ETV6:: RUNX1 is the most common fusion gene in childhood acute lymphoblastic
leukemia (ALL) associated with favorable prognosis, but the optimal therapy for this subtype …

Abstract The t (12; 21)(p13; q22) chromosomal translocation is the most frequent
translocation in childhood B cell precursor-acute lymphoblastic leukemia and results in the …