Microbial infections are controlled by host inflammatory responses that are initiated by
innate immune receptors after recognition of conserved microbial products. As inflammation …

The emergence of multiantibiotic-resistant bacteria, often referred to as superbugs, is
leading to infections that are increasingly difficult to treat. Further, bacteria have evolved …

Invasive fungal pathogens are major causes of human mortality and morbidity,. Although
numerous secreted effector proteins that reprogram innate immunity to promote virulence …

Many Gram-negative bacterial pathogens antagonize anti-bacterial immunity through
translocated effector proteins that inhibit pro-inflammatory signaling. In addition, the …

Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …

Macrophages function as tissue-immune sentinels and mediate key antimicrobial responses
against bacterial pathogens. Yet, they can also act as a cellular niche for intracellular …

Macrophages mediate key antimicrobial responses against intracellular bacterial
pathogens, such as Salmonella enterica. Yet, they can also act as a permissive niche for …

Highlights•While TS persistence is mostly asymptomatic, nontyphoidal Salmonella serovars
often remain symptomatic during persistence.•Anti-inflammatory M2-like macrophages are a …

Salmonella is one of the most important enteric pathogens worldwide, which is able to cause
lethal systemic infection via survival and replication in host macrophages. Lactate, a …

Invasive fungal infections pose a major threat to human health. Bacterial and protozoan
pathogens secrete protein effectors that overcome innate immune barriers to promote …