Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are
small (104 amino acids) and have a striking relationship to the acute phase response with …

Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute …

The incidence and severity of chronic lung diseases is growing and affects between 100 and
150 million people worldwide and is associated with a significant rate of mortality …

Comorbidities, are common in COPD, have been associated with poor outcomes and are
thought to relate to systemic inflammation. To investigate comorbidities in relation to …

Airway neutrophilia is a common feature of many chronic inflammatory lung diseases and is
associated with disease progression, often regardless of the initiating cause. Neutrophils …

Exacerbations of chronic obstructive pulmonary disease (COPD) are episodes of worsening
of symptoms, leading to substantial morbidity and mortality. COPD exacerbations are …

Objective Patients with COPD are at risk for cardiovascular events. This is attributed to
increased systemic inflammation. The course of COPD is punctuated by exacerbations …

Background Muscle wasting and chronic inflammation are predominant features of patients
with COPD. Systemic inflammation is associated with an accelerated decline in lung …

The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …

Rationale: Respiratory virus infections are associated with chronic obstructive pulmonary
disease (COPD) exacerbations, but a causative relationship has not been proven. Studies of …