Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

Inhibition of protein–protein interactions (PPIs) represents a significant challenge because it
is unclear how they can be effectively and selectively targeted using small molecules …

Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and
are implicated in epithelial to mesenchymal transition, cell-cycle progression …

Through the introduction of an aryl chloride substituent, the selectivity of palladium-catalyzed
direct arylation may be diverted to provide alternative regioisomeric products in high yields …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Targeting protein–protein interactions (PPIs) has emerged as a viable approach in modern
drug discovery. However, the identification of small molecules enabling us to effectively …

The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …

Many biological processes are regulated by protein–protein interactions (PPIs) and as such
their misregulation can cause a multitude of diseases. Often the interactions between large …

Protein–protein interactions (PPI) are vital in modulating biochemical pathways in many
biological processes. Inhibiting PPI is a tremendously important diagnostic and therapeutic …