Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

In the past few years genetic, biochemical, and cytolocalization data have implicated
members of the myosin superfamily of actin-based molecular motors in a variety of cellular …

The mouse represents an excellent model system for the study of genetic deafness in
humans. Many mouse deafness mutants have been identified and the anatomy of the mouse …

The early Drosophila embryo undergoes two distinct membrane invagination events
believed to be mechanistically related to cytokinesis: metaphase furrow formation and …

The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival,
is constitutively active in various human cancers, including ovarian. We have found that JAK …

The mouse mutant Snell's waltzer (sv) has an intragenic deletion of the Myo6 gene, which
encodes the unconventional myosin molecule myosin VI (KB Avraham et al., 1995, Nat …

Mutations in the unconventional myosin VI gene, Myo6, are associated with deafness and
vestibular dysfunction in the Snell's waltzer (sv) mouse. The corresponding human gene …

Centrosomin is a 150 kDa centrosomal protein of Drosophila melanogaster. To study the
function of Centrosomin in the centrosome, we have recovered mutations that are viable but …

Cosegregation of profound, congenital deafness with markers on chromosome 6q13 in three
Pakistani families defines a new recessive deafness locus, DFNB37. Haplotype analyses …

Myosin VI (MyoVI) is a pointed-end-directed, actin-based motor protein,, and mutations in
the gene result in disorganization of hair cell stereocilia and cause deafness in mice. MyoVI …