Prostate cancer histopathology using label-free multispectral deep-UV microscopy quantifies phenotypes of tumor aggressiveness and enables multiple diagnostic …

S Soltani, A Ojaghi, H Qiao, N Kaza, X Li, Q Dai… - Scientific Reports, 2022 - nature.com
Identifying prostate cancer patients that are harboring aggressive forms of prostate cancer
remains a significant clinical challenge. Here we develop an approach based on …

Label-free hematology analysis using deep-ultraviolet microscopy

A Ojaghi, G Carrazana, C Caruso… - Proceedings of the …, 2020 - National Acad Sciences
Hematological analysis, via a complete blood count (CBC) and microscopy, is critical for
screening, diagnosing, and monitoring blood conditions and diseases but requires complex …

Reflection-mode virtual histology using photoacoustic remote sensing microscopy

K Bell, S Abbasi, D Dinakaran, M Taher, G Bigras… - Scientific reports, 2020 - nature.com
Histological visualizations are critical to clinical disease management and are fundamental
to biological understanding. However, current approaches that rely on bright-field …

All-optical reflection-mode microscopic histology of unstained human tissues

S Abbasi, M Le, B Sonier, D Dinakaran, G Bigras… - Scientific reports, 2019 - nature.com
Surgical oncologists depend heavily on visual field acuity during cancer resection surgeries
for in-situ margin assessment. Clinicians must wait up to two weeks for results from a …

Compact Morpho‐Molecular Microscopy for Live‐cell Imaging and Material Characterization

M Niu, Y Wang, L Duan, R Sun… - Laser & Photonics …, 2024 - Wiley Online Library
Abstract The Compact Morpho‐Molecular Microscopy (CM3) is proposed and demonstrated
for multi‐functional imaging and characterization of living cells and material structures by …

[HTML][HTML] Virtual staining, segmentation, and classification of blood smears for label-free hematology analysis

E RoblesFrancisco - BME frontiers, 2022 - spj.science.org
Abstract Objective and Impact Statement. We present a fully automated hematological
analysis framework based on single-channel (single-wavelength), label-free deep-ultraviolet …

Hemoglobin quantification in red blood cells via dry mass mapping based on UV absorption

N Kaza, A Ojaghi, FE Robles - Journal of Biomedical Optics, 2021 - spiedigitallibrary.org
Significance: The morphological properties and hemoglobin (Hb) content of red blood cells
(RBCs) are essential biomarkers to diagnose or monitor various types of hematological …

Rapid and label-free histological imaging of unprocessed surgical tissues via dark-field reflectance ultraviolet microscopy

S Ye, J Zou, C Huang, F Xiang, Z Wen, N Wang, J Yu… - iScience, 2023 - cell.com
Routine examination for intraoperative histopathologic assessment is lengthy and laborious.
Here, we present the dark-field reflectance ultraviolet microscopy (DRUM) that enables label …

Compact and low-cost deep-ultraviolet microscope system for label-free molecular imaging and point-of-care hematological analysis

V Gorti, N Kaza, EK Williams, WA Lam… - Biomedical Optics …, 2023 - opg.optica.org
Deep-ultraviolet (UV) microscopy enables label-free, high-resolution, quantitative molecular
imaging and enables unique applications in biomedicine, including the potential for fast …

Unfolding and aggregation of lysozyme under the combined action of dithiothreitol and guanidine hydrochloride: Optical studies

RM Sarimov, VN Binhi, TA Matveeva… - International Journal of …, 2021 - mdpi.com
Using a number of optical techniques (interferometry, dynamic light scattering, and
spectroscopy), denaturation of hen egg white lysozyme (HEWL) by treatment with a …