Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a
key player in pathogenic ocular neovascularization almost a decade ago. Since then, an …

Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

During bone modeling, remodeling, and bone fracture repair, mesenchymal stem cells
(MSCs) differentiate into chondrocyte or osteoblast to comply bone formation and …

Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently
discovered that crocin, a dietary carotenoid derived from the Himalayan crocus, inhibited the …

Objective Acute kidney injury (AKI) is a common complication of acute liver failure (ALF).
Pyroptosis is a necrosis type related to inflammation. This study aimed to investigate the role …

Increased subchondral bone angiogenesis with blood vessels breaching the tidemark into
the avascular cartilage is a diagnostic feature of human osteoarthritis. However, the …

Background. In the past decade, mesenchymal stem cells (MSCs) have been widely used
for the treatment of osteoarthritis (OA), and noncoding RNAs in exosomes may play a major …

Angiogenesis, the growth of new blood vessels, is essential in the pathogenesis of joint
inflammatory disorders such as rheumatoid arthritis (RA) and osteoarthritis (OA), facilitating …

Osteoarthritis (OA) is the most common type of arthritis with no effective therapy.
Subchondral bone and overlying articular cartilage are closely associated and function as …