Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression
AE Campbell, MC Dyle, R Albanese, T Matheny… - Cell reports, 2023 - cell.com
Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination
codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However …
codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However …
Regulatory start-stop elements in 5'untranslated regions pervasively modulate translation
Various mechanisms controlling ribosome scanning and initiation have been identified
within the 5'untranslated region (UTR) of eukaryotic genes, including upstream open …
within the 5'untranslated region (UTR) of eukaryotic genes, including upstream open …
ggRibo: a ggplot-based single-gene viewer for visualizing Ribo-seq and related omics datasets
Visualizing periodic Ribo-seq data within genes of interest is a powerful approach to
studying mRNA translation, but its application is limited by a lack of robust tools. Here, we …
studying mRNA translation, but its application is limited by a lack of robust tools. Here, we …
Nonsense-mediated decay is not a major mechanism for regulating the uORF-containing mRNAs in Arabidopsis
ABSTRACT Background Upstream ORFs (uORFs) are widespread cis-regulatory elements
in the 5'untranslated regions of eukaryotic genes. In addition to repressing main ORF …
in the 5'untranslated regions of eukaryotic genes. In addition to repressing main ORF …