Cardiac disorders and pathophysiology of sarcomeric proteins
J van der Velden, GJM Stienen - Physiological reviews, 2019 - journals.physiology.org
The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …
essential for contraction and relaxation. During recent years, it has become evident that …
The sliding filament theory since Andrew Huxley: multiscale and multidisciplinary muscle research
Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …
muscle contraction based on force-generating interactions between myofilaments in the …
Troponin structure and function: a view of recent progress
S Marston, JE Zamora - Journal of muscle research and cell motility, 2020 - Springer
The molecular mechanism by which Ca 2+ binding and phosphorylation regulate muscle
contraction through Troponin is not yet fully understood. Revealing the differences between …
contraction through Troponin is not yet fully understood. Revealing the differences between …
Implications of S-glutathionylation of sarcomere proteins in cardiac disorders, therapies, and diagnosis
PC Rosas, RJ Solaro - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
The discovery that cardiac sarcomere proteins are substrates for S-glutathionylation and that
this post-translational modification correlates strongly with diastolic dysfunction led to new …
this post-translational modification correlates strongly with diastolic dysfunction led to new …
Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation
Tropomyosin, controlled by troponin-linked Ca 2+-binding, regulates muscle contraction by
a macromolecular scale steric-mechanism that governs myosin-crossbridge–actin …
a macromolecular scale steric-mechanism that governs myosin-crossbridge–actin …
Multi-scale modeling of the cardiovascular system: disease development, progression, and clinical intervention
Cardiovascular diseases (CVDs) are the leading cause of death in the western world. With
the current development of clinical diagnostics to more accurately measure the extent and …
the current development of clinical diagnostics to more accurately measure the extent and …
Atomic resolution probe for allostery in the regulatory thin filament
MR Williams, SJ Lehman, JC Tardiff… - Proceedings of the …, 2016 - National Acad Sciences
Calcium binding and dissociation within the cardiac thin filament (CTF) is a fundamental
regulator of normal contraction and relaxation. Although the disruption of this complex …
regulator of normal contraction and relaxation. Although the disruption of this complex …
Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility
Cardiac troponin (cTn) acts as a pivotal regulator of muscle contraction and relaxation and is
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …
Umbrella sampling simulations measure switch peptide binding and hydrophobic patch opening free energies in cardiac troponin
AM Cool, S Lindert - Journal of chemical information and …, 2022 - ACS Publications
The cardiac troponin (cTn) complex is an important regulatory protein in heart contraction.
Upon binding of Ca2+, cTn undergoes a conformational shift that allows the troponin I switch …
Upon binding of Ca2+, cTn undergoes a conformational shift that allows the troponin I switch …
Cardiac myosin-binding protein C and troponin-I phosphorylation independently modulate myofilament length-dependent activation
β-Adrenergic stimulation in heart leads to increased contractility and lusitropy via activation
of protein kinase A (PKA). In the cardiac sarcomere, both cardiac myosin binding protein C …
of protein kinase A (PKA). In the cardiac sarcomere, both cardiac myosin binding protein C …