Infant acute leukaemia is characterised by specific genetic rearrangements and a rapid
onset of disease shortly after birth. The vast majority of these cases bear rearranged MLL …

The myelodysplastic syndromes (MDSs) are common, acquired, clinically challenging
hematologic conditions that are characterized by bone marrow failure and a risk of …

Recurring deletions of chromosome 7 and 7q [− 7/del (7q)] occur in myelodysplastic
syndromes and acute myeloid leukemia (AML) and are associated with poor prognosis …

Patients treated with cytotoxic therapies, including autologous stem cell transplantation, are
at risk for developing therapy-related myeloid neoplasms (tMN). Preleukemic clones (ie …

Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenotyping and karyotype …

In the past few years, new biological insights into the myelodysplastic syndromes (MDS)
resulting from molecular genetic analysis have improved pathologic understanding, but …

Childhood leukemias are heterogeneous diseases with widely differing incident rates
worldwide. As circulating tumors, childhood acute leukemias are uniquely accessible, and …

TRAF-interacting protein with forkhead-associated domain B (TIFAB) is a haploinsufficient
gene in del (5q) myelodysplastic syndrome (MDS). Deletion of Tifab results in progressive …

The present invention relates to peptides, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …

The master regulatory transcription factor GATA-2 triggers hematopoietic stem and
progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic …