The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …

The human protein kinome comprises 535 proteins that, with the exception of approximately
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Kinome-wide profiling platforms have comprehensively identified the relevant kinases that
are targeted by numerous protein kinase inhibitors. However, recent projects have begun to …

To date, five cancer treatment modalities have been defined. The three traditional modalities
of cancer treatment are surgery, radiotherapy, and conventional chemotherapy, and the two …

The pseudokinase complement of the human kinase superfamily consists of approximately
60 signaling proteins, which lacks one or more of the amino acids typically required to …

Over the past decade, our understanding of the mechanisms by which pseudokinases,
which comprise∼ 10% of the human and mouse kinomes, mediate signal transduction has …

A major challenge associated with biochemical and cellular analysis of pseudokinases is a
lack of target-validated small-molecule compounds with which to probe function. Tribbles 2 …

The human Tribbles (TRB)-related pseudokinases are CAMK (calcium/calmodulin-
dependent protein kinase)-related family members that have evolved a series of highly …

Despite their apparent lack of catalytic activity, pseudokinases are essential signaling
molecules. Here, we describe the structural and dynamic properties of pseudokinase …