Abstract Polyvinylpyrrolidone (PVP), a non-ionic polymer, has been employed in multifarious
fields such as paper, fibers and textiles, ceramics, and pharmaceutics due to its superior …

In the pharmaceutical industry, poorly water-soluble drugs require enabling technologies to
increase apparent solubility in the biological environment. Amorphous solid dispersion …

Hot melt extrusion (HME) can be used to produce amorphous solid dispersions (ASDs) at
temperatures below the drug's melting point if the drug and polymer exhibit melting point …

Crystalline solid dispersions (CSDs) represent a thermodynamically stable system capable
of effectively reducing the crystallite size of drugs, thereby enhancing their solubility and …

Co-amorphous strategy has been extensively investigated to improve the dissolution of
hydrophobic drugs. Here, epigallocatechin-3-gallate (EGCG) was exploited as a co-former …

Currently, most amorphous solid dispersion (ASD) formulations contain a single polymer to
stabilize an amorphous drug. However, a single polymer has a limited ability to form strong …

Polymers functionally contribute to supersaturation and precipitation inhibition of the active
pharmaceutical ingredient (API) in amorphous solid dispersions (ASD). Therefore, it is …

The dissolution or melting of a crystalline drug into a molten polymeric matrix underpins the
fabrication of a number of drug delivery systems. However, little is known about how crystals …

This study investigated the drug–polymer miscibility, intermolecular interaction, physical
stability, and dissolution performance of amorphous solid dispersions (ASDs) of norfloxacin …

This investigation aims to evaluate the effect of moisture and temperature on the physical
stability and dissolution behaviour of hot-melt extruded binary and plasticised ternary solid …