Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and
cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development …

Noroviruses are the most common cause of food-borne gastroenteritis worldwide, and
explosive outbreaks frequently occur in community settings, where the virus can immobilize …

The outcome of a viral infection is regulated in part by the complex coordination of viral and
host interactions that compete for the control and optimization of virus replication. Severe …

Vaccination is arguably the most cost-effective preventative measure against infectious
diseases. While vaccines have been successfully developed against certain viruses (eg …

Background In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV) was
identified as the etiological agent of severe acute respiratory syndrome, a disease …

Malaria causes much physical and economic hardship in tropical regions, particularly in
communities where medical care is rudimentary. Should a vaccine be developed, it is the …

Recombinant nucleic acids are considered as promising next-generation vaccines. These
vaccines express the native antigen upon delivery into tissue, thus mimicking live attenuated …

Alphavirus replicon particle-based vaccine vectors derived from Sindbis virus (SIN), Semliki
Forest virus, and Venezuelan equine encephalitis virus (VEE) have been shown to induce …

Abstract The International AIDS Vaccine Initiative has established a consortium to elucidate
mechanisms of protection conferred by live attenuated simian immunodeficiency virus …

Alphaviruses are positive‐stranded RNA viruses that have a broad host range and therefore
are capable of replicating in many vertebrate and invertebrate cells. The single‐stranded …