Drosophila melanogaster has been the subject of research into central questions about
biological mechanisms for almost a century. The experimental tools and resources that are …

Abstract The Berkeley Drosophila Genome Project (BDGP) strives to disrupt each
Drosophila gene by the insertion of a single transposable element. As part of this effort …

A fundamental goal of genetics and functional genomics is to identify and mutate every gene
in model organisms such as Drosophila melanogaster. The Berkeley Drosophila Genome …

Abstract Members of the Hedgehog (Hh) family of secreted signaling proteins function as
potent short-range organizers in animal development. Their range of action is limited by a C …

Sphingolipids are important structural components of membranes that delimit the
boundaries of cellular compartments, cells and organisms. They play an equally important …

One of the most dominant influences in the patterning of multicellular embryos is exerted by
the Hedgehog (Hh) family of secreted signaling proteins. Here, we identify a segment …

Drosophila has robust behavioral plasticity to avoid or prefer the odor that predicts
punishment or food reward, respectively. Both types of plasticity are mediated by the …

Despite recent advances in developmental biology, and the sequencing and annotation of
genomes, key questions regarding the organisation of cells into embryos remain. One …

The body axes of Drosophila are established during oogenesis through reciprocal
interactions between the germ line cells and the somatic follicle cells that surround them …

Correct pathfinding by Drosophila photoreceptor axons requires recruitment of p21-activated
kinase (Pak) to the membrane by the SH2-SH3 adaptor Dock. Here, we identify the guanine …