Hyperglycemia-driven signaling bridges between diabetes and cancer

S Ghareghomi, P Arghavani, M Mahdavi… - Biochemical …, 2024 - Elsevier
Growing epidemiological evidence indicates an association between obesity, type 2
diabetes, and certain cancers, suggesting the existence of common underlying mechanisms …

Why does obesity as an inflammatory condition predispose to colorectal cancer?

AM Rychter, L Łykowska-Szuber, A Zawada… - Journal of Clinical …, 2023 - mdpi.com
Obesity is a complex and multifactorial problem of global importance. Additionally, obesity
causes chronic inflammation, upregulates cell growth, disturbs the immune system, and …

Type 2 Diabetes and colorectal cancer risk

T Lawler, ZL Walts, M Steinwandel… - JAMA Network …, 2023 - jamanetwork.com
Importance Type 2 diabetes and colorectal cancer (CRC) disproportionately burden
indviduals of low socioeconomic status and African American race. Although diabetes is an …

Metabolic alteration bridging the prediabetic state and colorectal cancer

A Colloca, I Donisi, C Anastasio, ML Balestrieri… - Cells, 2024 - mdpi.com
Prediabetes and colorectal cancer (CRC) represent compelling health burdens responsible
for high mortality and morbidity rates, sharing several modifiable risk factors. It has been …

Identifying key genes against rutin on human colorectal cancer cells via ROS pathway by integrated bioinformatic analysis and experimental validation

MK Gatasheh - Computational Biology and Chemistry, 2024 - Elsevier
Colorectal cancer (CRC) poses a significant global health challenge, characterized by
substantial prevalence variations across regions. This study delves into the therapeutic …

Causal linkage between type 2 diabetes mellitus and inflammatory bowel disease: an integrated Mendelian randomization study and bioinformatics analysis

X Xiao, X Wu, L Yi, F You, X Li, C Xiao - Frontiers in Endocrinology, 2024 - frontiersin.org
Background Observational studies have indicated associations between type 2 diabetes
mellitus (T2DM) and both colorectal cancer (CRC) and inflammatory bowel disease (IBD) …

Micro-Current Stimulation Can Modulate the Adipogenesis Process by Regulating the Insulin Signaling Pathway in 3T3-L1 Cells and ob/ob Mice

H Lee, JH Lee, D Kim, D Hwang, M Lee, H Chung… - Life, 2023 - mdpi.com
Obesity is a disease in which fat is abnormally or excessively accumulated in the body, and
many studies have been conducted to overcome it with various techniques. In this study, we …

Diabetes and other comorbidities: Microvascular and macrovascular diseases diabetes and cancer

V Nithya, P Sangavi, R Srinithi, KT Nachammai… - Advances in diabetes …, 2023 - Springer
Diabetes is characterized by unusually elevated blood glucose or levels of sugar. Dietary
glucose is produced, and insulin is the hormone that aids glucose entry into cells to provide …

Associations of diabetes and mortality among colorectal cancer patients from the Southern Community Cohort Study

T Lawler, E Hibler, ZL Walts, L Giurini… - British Journal of …, 2024 - nature.com
Background We investigated associations between diabetes and mortality among
participants with incident colorectal cancer (CRC) from the Southern Community Cohort …

Seroreactivity against tyrosine phosphatase PTPRN links Type 2 Diabetes and Colorectal Cancer and identifies a Potential diagnostic and Therapeutic Target

M Garranzo-Asensio, G Solís-Fernández… - Diabetes, 2022 - Am Diabetes Assoc
Colorectal cancer (CRC) and diabetes are two of the most prevalent chronic diseases
worldwide with dysregulated receptor tyrosine kinase signaling and strong co-occurrence …