The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

The maternal vasculature within the placenta in primates and rodents is unique because it is
lined by fetal cells of the trophoblast lineage and not by maternal endothelial cells. In …

Malaria remains a highly prevalent disease in more than 90 countries and accounts for at
least 1 million deaths every year. Plasmodium falciparum infection is often associated with a …

Absence of the blood coagulation inhibitor thrombomodulin (Thbd) from trophoblast cells of
the mouse placenta causes a fatal arrest of placental morphogenesis. The pathogenesis of …

Background Pre-eclampsia is a complication of pregnancy associated with activation of
coagulation. It is caused by the placenta, which sheds increased amounts of …

Upon activation, maternal platelets provide a source of proinflammatory mediators in the
intervillous space of the placenta. Therefore, platelet-derived factors may interfere with …

Introduction Protease inhibitors, including the Kunitz, Kazal, serpin and mucus families, play
important roles in inhibiting protease activities during homeostasis, inflammation, tissue …

Recurrent miscarriages and pregnancy-related complications cause significant stress to
couples looking for successful pregnancy outcome as well as to health care professionals …

Background Patients with amniotic fluid embolism (AFE)(major cardiac and pulmonary
symptoms plus consumptive coagulopathy) have high circulating tissue factor …

The hemostasis system is composed of procoagulant, anticoagulant, and fibrinolytic proteins
that interact with endothelial and blood cells and with each other in a complex system of …