• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Background: Left atrial appendage (LAA) occlusion provides an alternative to oral
anticoagulation for thromboembolic risk reduction in patients with nonvalvular atrial …

Background Data on the impact of residual peri-device leak after left atrial appendage
occlusion (LAAO) are limited. Objectives The goal of this study was to explore the …

Exclusion of the left atrial appendage to reduce thromboembolic risk related to atrial
fibrillation was first performed surgically in 1949. Over the past 2 decades, the field of …

Background Pivotal trials of percutaneous left atrial appendage occlusion (LAAO) used
specific postprocedure treatment protocols. Objectives This study sought to evaluate …

Importance Undertreatment of older adults with atrial fibrillation with anticoagulation therapy
is an important practice gap. It has been posited that the availability of direct oral …

Importance Left atrial appendage occlusion (LAAO) has emerged as an alternative to
anticoagulation for select patients with atrial fibrillation; however, women have been …

The majority of embolic strokes in patients with nonvalvular atrial fibrillation are caused by
thrombi in the left atrial appendage. It is projected that strokes related to atrial fibrillation will …

Electronic databases were searched from inception until June 23, 2020, for RCTs comparing
LAAC versus OAC in nonvalvular AF. Outcomes were all-stroke/systemic embolism (SE) …