Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering

N Fahy, M Alini, MJ Stoddart - Journal of Orthopaedic Research …, 2018 - Wiley Online Library
Articular cartilage is a load‐bearing tissue playing a crucial mechanical role in diarthrodial
joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical …

Functional significance of cell volume regulatory mechanisms

F Lang, GL Busch, M Ritter, H Volkl… - Physiological …, 1998 - journals.physiology.org
Lang, Florian, Gillian L. Busch, Markus Ritter, Harald Völkl, Siegfried Waldegger, Erich
Gulbins, and Dieter Häussinger. Functional Significance of Cell Volume Regulatory …

[HTML][HTML] Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures

MMJ Caron, PJ Emans, MME Coolsen, L Voss… - Osteoarthritis and …, 2012 - Elsevier
OBJECTIVE: Three-dimensional (3D) cultures are widely used to redifferentiate
chondrocytes. However, the rationale behind the choice for 3D above two-dimensional (2D) …

Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions

KL Cooper, S Oh, Y Sung, RR Dasari, MW Kirschner… - Nature, 2013 - nature.com
The wide diversity of skeletal proportions in mammals is evident upon a survey of any
natural history museum's collections and allows us to distinguish between species even …

Application of alginate hydrogels for next-generation articular cartilage regeneration

W Liu, H Madry, M Cucchiarini - International Journal of Molecular …, 2022 - mdpi.com
The articular cartilage has insufficient intrinsic healing abilities, and articular cartilage
injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials …

Bioprinting complex cartilaginous structures with clinically compliant biomaterials

M Kesti, C Eberhardt, G Pagliccia… - Advanced Functional …, 2015 - Wiley Online Library
Bioprinting is an emerging technology for the fabrication of patient‐specific, anatomically
complex tissues and organs. A novel bioink for printing cartilage grafts is developed based …

Cartilage tissue remodeling in response to mechanical forces

AJ Grodzinsky, ME Levenston, M Jin… - Annual review of …, 2000 - annualreviews.org
▪ Abstract Recent studies suggest that there are multiple regulatory pathways by which
chondrocytes in articular cartilage sense and respond to mechanical stimuli, including …

The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules

H Muir - Bioessays, 1995 - Wiley Online Library
Chondrocytes are specialised cells which produce and maintain the extracellular matrix of
cartilage, a tissue that is resilient and pliant. In vivo, it has to withstand very high …

The role of chondrocyte morphology and volume in controlling phenotype—implications for osteoarthritis, cartilage repair, and cartilage engineering

AC Hall - Current Rheumatology Reports, 2019 - Springer
Abstract Purpose of Review Articular chondrocytes are exclusively responsible for the
turnover of the extracellular matrix (ECM) of hyaline cartilage. However, chondrocytes are …

Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study

F Guilak, A Ratcliffe, VC Mow - Journal of Orthopaedic …, 1995 - Wiley Online Library
It is well accepted that mechanical forces can modulate the metabolic activity of
chondrocytes, although the specific mechanisms of mechanical signal transduction in …