In this review, we summarize the origin and advancements of iridium-catalyzed asymmetric
allylic substitution reactions during the past two decades. Since the first report in 1997, Ir …

The asymmetric alkylation of enolates is a particularly versatile method for the construction
of α-stereogenic carbonyl motifs, which are ubiquitous in synthetic chemistry. Over the past …

Allylation reactions are one of the most fundamental and productive C− C bond-forming
transformations, as the allyl group can provide a useful handle for further manipulation …

The construction of acyclic, non‐adjacent 1, 3‐stereogenic centers, prevalent motifs in drugs
and bioactive molecules, has been a long‐standing synthetic challenge due to acyclic …

An Ir/Zn dual catalysis has been developed for the enantio-and diastereodivergent α-
allylation of unprotected α-hydroxyketones under mild conditions, in the absence of any …

The preparation of all possible stereoisomers of a given chiral molecule bearing multiple
stereocenters by a simple and unified method is a significant challenge in asymmetric …

Chiral monophosphorus ligands are playing an important role for the recent advances in
asymmetric catalysis. This review summarizes the latest progress in various asymmetric …

2.1. Acyclic Nucleophiles. In 2003, Takemoto and coworkers reported the first example of a
diastereo-, enantio-, and regioselective iridium-catalyzed allylic alkylation (Scheme 3). 8 The …

The stereodivergent iridium‐catalyzed allylic alkylation and fluorination of acyclic ketones is
described. α‐Pyridyl‐α‐fluoroketones with vicinal tertiary and quaternary stereocenters were …

An iridium‐catalyzed intramolecular asymmetric allylic dearomatization reaction of naphthol
derivatives is described. Challenges confronted in this reaction include chemoselectivity …