Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM)
and this appears to underlie the development of cardiovascular disease, T2DM and diabetic …

Age is a non-modifiable risk factor for the inflammation that underlies age-associated
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …

This systematic review and meta-analysis is the first to evaluate the evidence for an
association between metformin use and cancer outcomes in patients undergoing treatment …

Obesity is reported to be a chronic low-grade inflammatory state. Adipose tissue
macrophages play a key role in obesity-related inflammation. Metformin, the most widely …

Metformin is a biguanide drug widely used as the initial treatment of type 2 diabetes. Despite
its widespread use, its precise mechanisms of action remain incompletely characterised. Its …

Description: The American College of Physicians (ACP) developed this guideline to present
the evidence and provide clinical recommendations on oral pharmacologic treatment of type …

OBJECTIVE The two major classes of antidiabetic drugs, sulfonylureas and metformin, may
differentially affect macrovascular complications and mortality in diabetic patients. We …

The adenosine monophosphate-activated protein kinase (AMPK) is a metabolic sensor of
energy metabolism at the cellular as well as whole-body level. It is activated by low energy …

Background Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is
associated with severe morbidity and mortality and commonly seen in patients with diabetes …