The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

In recent years, the explosive spread of antibiotic resistance determinants among
pathogenic, commensal, and environmental bacteria has reached a global dimension …

The development of small molecules that target RNA is challenging yet, if successful, could
advance the development of chemical probes to study RNA function or precision …

Although fluorine plays only a minor role in biology, its physicochemical properties have
proven incredibly useful in the design of analogues of biologically important molecules …

The targeting of one mRNA in the transcriptome requires small molecules that bind with
substantial affinity and specificity. As such, compounds with specificity for individual RNA …

Bacteria carrying resistance genes for many antibiotics are moving beyond the clinic into the
community, infecting otherwise healthy people with untreatable and frequently fatal …

Antibiotic resistance increases the likelihood of death from infection by common pathogens
such as Escherichia coli and Klebsiella pneumoniae in developed and developing countries …

Herein, we report the development of a microarray platform to select RNA motif− ligand
interactions that allows simultaneous screening of both RNA and chemical space. We used …

Many multidrug-resistant bacterial pathogens harbor large plasmids that encode proteins
conferring resistance to antibiotics. Although the acquisition of these plasmids often enables …

Bacterial ribosomal RNA is the target of clinically important antibiotics, while biologically
important RNAs in viral and eukaryotic genomes present a range of potential drug targets …