Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs)
that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are …

G protein-coupled receptors (GPCRs) are the largest group of cell surface receptors in
humans that signal in response to diverse inputs and regulate a plethora of cellular …

G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete
understanding of how they signal through 16 non-visual G-protein signal transducers …

G-protein-coupled receptors (GPCRs), the largest family of signalling receptors, as well as
important drug targets, are known to activate extracellular-signal-regulated kinase (ERK)—a …

The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …

G protein-coupled receptors (GPCRs) are privileged structural scaffolds in biology that have
the versatility to regulate diverse physiological processes. Interestingly, many GPCR ligands …

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Binding of arrestin to phosphorylated G protein-coupled receptors (GPCRs) is crucial for
modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins …

Abstract Neurotensin receptor 1 (NTSR1) is a G-protein-coupled receptor (GPCR) that
engages multiple subtypes of G protein, and is involved in the regulation of blood pressure …

G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every
aspect of cell function. Studies of GPCRs have benefited greatly from the development of …