Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies

K Sumaiya, D Langford, K Natarajaseenivasan… - Pharmacology & …, 2022 - Elsevier
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

Nanobodies: robust miniprotein binders in biomedicine

JYJ Kim, Z Sang, Y Xiang, Z Shen, Y Shi - Advanced Drug Delivery …, 2023 - Elsevier
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …

Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus

JB Bilsborrow, E Doherty, PV Tilstam… - Expert opinion on …, 2019 - Taylor & Francis
Introduction. Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory
cytokine with upstream regulatory roles in innate and adaptive immunity and is implicated in …

Research progress and applications of nanobody in human infectious diseases

Y Mei, Y Chen, JP Sivaccumar, Z An, N Xia… - Frontiers in …, 2022 - frontiersin.org
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises.
In addition to persistent infectious diseases such as malaria and dengue fever, the vicious …

Exploring cellular biochemistry with nanobodies

RW Cheloha, TJ Harmand, C Wijne… - Journal of Biological …, 2020 - ASBMB
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Macrophage migration inhibitory factor (MIF)-based therapeutic concepts in atherosclerosis and inflammation

D Sinitski, C Kontos, C Krammer… - Thrombosis and …, 2019 - thieme-connect.com
Chemokines orchestrate leukocyte recruitment in atherosclerosis and their blockade is a
promising anti-atherosclerotic strategy, but few chemokine-based approaches have …

Macrophage migration inhibitory factor (MIF) as a stress molecule in renal inflammation

YZ Kong, Q Chen, HY Lan - International Journal of Molecular Sciences, 2022 - mdpi.com
Renal inflammation is an initial pathological process during progressive renal injury
regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly …

Hallmarks of cancer affected by the MIF cytokine family

R Mora Barthelmess, B Stijlemans… - Cancers, 2023 - mdpi.com
Simple Summary The aim of this review is to summarize the available information regarding
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …

A few good reasons to use nanobodies for cancer treatment

NA Jumapili, M Zivalj, RM Barthelmess… - European Journal of …, 2023 - Wiley Online Library
Abstract mAbs have been instrumental for targeted cancer therapies. However, their
relatively large size and physicochemical properties result in a heterogenous distribution in …

Engineered multivalent nanobodies potently and broadly neutralize SARS‐CoV‐2 variants

JM Zupancic, JS Schardt, AA Desai… - Advanced …, 2021 - Wiley Online Library
The COVID‐19 pandemic continues to be a severe threat to human health, especially due to
current and emerging SARS‐CoV‐2 variants with potential to escape humoral immunity …