Nasopharyngeal carcinoma: an evolving paradigm

KCW Wong, EP Hui, KW Lo, WKJ Lam… - Nature reviews Clinical …, 2021 - nature.com
The past three decades have borne witness to many advances in the understanding of the
molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein–Barr virus …

Epstein Barr virus: development of vaccines and immune cell therapy for EBV-associated diseases

X Cui, CM Snapper - Frontiers in Immunology, 2021 - frontiersin.org
Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated
in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated …

Nasopharyngeal carcinoma

MLK Chua, JTS Wee, EP Hui, ATC Chan - The Lancet, 2016 - thelancet.com
Epidemiological trends during the past decade suggest that although incidence of
nasopharyngeal carcinoma is gradually declining, even in endemic regions, mortality from …

Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy

M Canning, G Guo, M Yu, C Myint… - Frontiers in cell and …, 2019 - frontiersin.org
Head and neck squamous cell carcinomas (HNSCCs) are highly aggressive, multi-factorial
tumors in the upper aerodigestive tract affecting more than half a million patients worldwide …

Management of nasopharyngeal carcinoma: current practice and future perspective

AWM Lee, BBY Ma, WT Ng, ATC Chan - Journal of clinical oncology, 2015 - ascopubs.org
Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China,
and patient prognosis has improved significantly over the past three decades because of …

The immunology of Epstein-Barr virus–induced disease

GS Taylor, HM Long, JM Brooks… - Annual review of …, 2015 - annualreviews.org
Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …

The role of Epstein–Barr virus in nasopharyngeal carcinoma

ZY Su, PY Siak, CO Leong, SC Cheah - Frontiers in Microbiology, 2023 - frontiersin.org
Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy closely associated
with the Epstein–Barr virus (EBV). Despite ubiquitous infection of EBV worldwide, NPC …

Current perspectives on nasopharyngeal carcinoma

HM Lee, KS Okuda, FE González, V Patel - … advances in cell models for the …, 2019 - Springer
Abstract Of the~ 129,079 new cases of nasopharyngeal carcinoma (NPC) and 72,987
associated deaths estimated for 2018, the majority will be geographically localized to South …

Improving chimeric antigen receptor-modified T cell function by reversing the immunosuppressive tumor microenvironment of pancreatic cancer

S Mohammed, S Sukumaran, P Bajgain, N Watanabe… - Molecular therapy, 2017 - cell.com
The adoptive transfer of T cells redirected to tumor-associated antigens via transgenic
expression of chimeric antigen receptors (CARs) has produced tumor responses, even in …

Cancer immunotherapies: from efficacy to resistance mechanisms–not only checkpoint matters

S Wang, K Xie, T Liu - Frontiers in immunology, 2021 - frontiersin.org
The immunotherapeutic treatment of various cancers with an increasing number of immune
checkpoint inhibitors (ICIs) has profoundly improved the clinical management of advanced …