[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome
The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated
rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to …
rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to …
Emerging therapeutic targets in the short QT syndrome
ABSTRACT Introduction: Short QT Syndrome (SQTS) is a rare but dangerous condition
characterised by abbreviated repolarisation, atrial and ventricular arrhythmias and risk of …
characterised by abbreviated repolarisation, atrial and ventricular arrhythmias and risk of …
Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles
The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and
sudden death. Gain-of-function mutations to potassium channels mediating the rapid …
sudden death. Gain-of-function mutations to potassium channels mediating the rapid …
Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling
Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT
syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 …
syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 …
Cardiac behaviors and chaotic arrhythmias in the Hindmarsh–Rose model
RV Stenzinger, TE Scalvin, PA Morelo… - Chaos, Solitons & …, 2023 - Elsevier
Abstract The Hindmarsh–Rose is one of the best-known models of computational
neuroscience. Despite its popularity as a neuron model, we demonstrate that it is also a …
neuroscience. Despite its popularity as a neuron model, we demonstrate that it is also a …
Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes
Short QT (SQT) syndrome is a genetic cardiac disorder characterized by an abbreviated QT
interval of the patient's electrocardiogram. The syndrome is associated with increased risk of …
interval of the patient's electrocardiogram. The syndrome is associated with increased risk of …
Investigating the complex arrhythmic phenotype caused by the gain-of-function mutation KCNQ1-G229D
X Zhou, A Bueno-Orovio, RJ Schilling, C Kirkby… - Frontiers in …, 2019 - frontiersin.org
The congenital long QT syndrome (LQTS) is a cardiac electrophysiological disorder that can
cause sudden cardiac death. LQT1 is a subtype of LQTS caused by mutations in KCNQ1 …
cause sudden cardiac death. LQT1 is a subtype of LQTS caused by mutations in KCNQ1 …
[HTML][HTML] Modelling the effects of chloroquine on KCNJ2-linked short QT syndrome
A gain-of-function KCNJ2 D172N mutation in KCNJ2-encoded Kir2. 1 channels underlies
one form of short QT syndrome (SQT3), which is associated with increased susceptibility to …
one form of short QT syndrome (SQT3), which is associated with increased susceptibility to …