Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …

Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident-
and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population …

Introduction: It has been proposed that an increased susceptivity to oxidative stress caused
by the absence of the protein dystrophin from the inner surface of the sarcolemma is a …

Diabetic myopathy is a co-morbidity diagnosed in most diabetes mellitus patients, yet its
pathogenesis is still understudied, which hinders the development of effective therapies …

Microtubules are a major component of the cytoskeleton and can accumulate a plethora of
modifications. The microtubule detyrosination cycle is one of these modifications; it involves …

Altered myofibrillar structure is a consequence of dystrophic pathology that impairs skeletal
muscle contractile function and increases susceptibility to contraction injury. In murine …

Skeletal muscle tissue function is governed by the mechanical properties and organization
of its components, including myofibers, extracellular matrix, and adipose tissue, which can …

The absence of dystrophin hypersensitizes skeletal muscle of lower and higher vertebrates
to eccentric contraction (ECC)-induced strength loss. Loss of strength can be accompanied …

The common null polymorphism (R577X) in the ACTN3 gene is present in over 1.5 billion
people worldwide and results in the absence of the protein α-actinin-3 from the Z-discs of …

In Duchenne muscular dystrophy (DMD), alterations in the myofibrillar structure of skeletal
muscle fibers that impair contractile function and increase injury susceptibility arise as a …