Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Recent applications of high resolution mass spectrometry for the characterization of plant natural products

G Alvarez-Rivera, D Ballesteros-Vivas… - TrAC Trends in …, 2019 - Elsevier
Recently, the high analytical power provided by the new HRMS instruments (working in the
MS or MS/MS mode, stand alone or hyphenated with separation techniques) is making more …

A review of the antimalarial, antitrypanosomal, and antileishmanial activities of natural compounds isolated from Nigerian flora

MA Ungogo, GU Ebiloma, N Ichoron, JO Igoli… - Frontiers in …, 2020 - frontiersin.org
The West African country Nigeria features highly diverse vegetation and climatic conditions
that range from rain forest bordering the Atlantic Ocean in the South to the Desert (Sahara) …

Low and high resolution gas chromatography-mass spectrometry for untargeted metabolomics: A tutorial

F Rey-Stolle, D Dudzik, C Gonzalez-Riano… - Analytica Chimica …, 2022 - Elsevier
GC-MS for untargeted metabolomics is a well-established technique. Small molecules and
molecules made volatile by derivatization can be measured and those compounds are key …

Expanding urinary metabolite annotation through integrated mass spectral similarity networking

FC Neto, D Raftery - Analytical chemistry, 2021 - ACS Publications
The urine metabolome constitutes a rich source of functional information reflecting
physiological states that are influenced by distinct conditions and biological stresses, such …

[HTML][HTML] Metabolômica de plantas: métodos e desafios

AC Pilon, DM Selegato, RP Fernandes, PCP Bueno… - Química …, 2020 - SciELO Brasil
Metabolomics has played a central role in various areas of plant sciences, offering new
perspectives for the advancement of agriculture, drug discovery, chemical ecology and …

Dereplication of flavonoid glycoconjugates from Adenocalymma imperatoris-maximilianii by untargeted tandem mass spectrometry-based molecular networking

GG de Oliveira, FC Neto, DP Demarque… - Planta …, 2017 - thieme-connect.com
The interpretation of large datasets acquired using high performance liquid chromatography
coupled with tandem mass spectrometry represents one of the major challenges in natural …

[HTML][HTML] Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC …

A Haiduc, F Zanetti, X Zhao, WK Schlage… - … of Chromatography B, 2020 - Elsevier
Tobacco smoking contributes to tooth discoloration. Pigmented compounds in the smoke
generated by combustion of tobacco can cause discoloration of dental hard tissues …

Combination of GC-MS Molecular Networking and Larvicidal Effect against Aedes aegypti for the Discovery of Bioactive Substances in Commercial Essential Oils

AC Pilon, M Del Grande, MRS Silvério, RR Silva… - Molecules, 2022 - mdpi.com
Dengue is a neglected disease, present mainly in tropical countries, with more than 5.2
million cases reported in 2019. Vector control remains the most effective protective measure …

Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach

SJ Ahmad, MBH Abdul Rahim… - Journal of tropical …, 2017 - Wiley Online Library
Natural products continue to play an important role as a source of biologically active
substances for the development of new drug. Streptomyces, Gram‐positive bacteria which …