Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …

The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

Protein ubiquitination is of great cellular importance through its central role in processes
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …

Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …

Regulated cellular proteolysis is mediated largely by the ubiquitin–proteasome system
(UPS). It is a highly specific process that is time-(eg cell cycle), compartment-(eg nucleus or …

Post-translational protein modifications initiate, regulate, propagate and terminate a wide
variety of processes in cells, and in particular, ubiquitylation targets substrate proteins for …

The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …

Lewy Body Disorders (LBDs) lie within the spectrum of age-related neurodegenerative
diseases now frequently categorized as the synucleinopathies. LBDs are considered to be …

Abstract The Ubiquitin Proteasome System (UPS) was discovered in two steps. Initially, APF-
1 (ATP-dependent proteolytic Factor 1) later identified as ubiquitin (Ub), a hitherto known …