Sepsis is a potentially fatal condition caused by dysregulation of the body's immune
response to an infection. Sepsis-induced liver injury is considered a strong independent …

Sepsis is a systemic inflammatory disease with infection, and autophagy has been shown to
play an important role in sepsis. This review summarizes the main regulatory mechanisms of …

Thymol is a natural antibacterial agent found in the essential oil extracted from thyme, which
has been proven to be beneficial in food and medicine. Meanwhile, the NOD-like receptor …

Background and Aims The proinflammatory cytokine IL‐1β has been implicated in the
pathophysiology of nonalcoholic and alcoholic steatohepatitis. How IL‐1β promotes liver …

Background Cholestasis, as a main manifestation, induces liver injury during sepsis. The
farnesoid X receptor (FXR) plays an important role in regulating bile acid homeostasis …

Sepsis is a dysregulated response to severe infection characterized by life-threatening
organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the …

Autophagy is the liver cell energy recycling system regulating a variety of homeostatic
mechanisms. Damaged organelles, lipids and proteins are degraded in the lysosomes and …

Liver fibrosis (LF) occurs as a result of persistent liver injury and can be defined as a
pathologic, chronic, wound‐healing process in which functional parenchyma is …

Intensive care unit acquired weakness (ICUAW) is now a well-known entity complicating
critical illness. It increases mortality and in the critical illness survivor it is associated with …

Uncontrollable inflammatory response acts as a driver of sepsis-associated liver injury
(SALI). IL-22 plays an important role in regulating inflammatory responses, but its role in …