The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

The neuromodulator melatonin synchronizes circadian rhythms and related physiological
functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian …

Neutrophil granulocytes play key roles in innate immunity and shaping adaptive immune
responses. They are attracted by chemokines to sites of infection and tissue damage, where …

Biased signaling of G protein-coupled receptors describes an ability of different ligands that
preferentially activate an alternative downstream signaling pathway. In this work, we …

The CC motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has
emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has …

CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but
chemokine network redundancy thwarts pharmacological intervention. Tick evasins …

G protein–coupled receptors (GPCRs), which mediate processes as diverse as olfaction and
maintenance of metabolic homeostasis, have become the single most effective class of …

Chronic Obstructive Pulmonary Disease (COPD) represents the 3rd leading cause of death
in the world. The underlying pathophysiological mechanisms have been the focus of …

Chemokines have two types of interactions that function cooperatively to control cell
migration. Chemokine receptors on migrating cells integrate signals initiated upon …