Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

The plasma membrane allows the cell to sense and adapt to changes in the extracellular
environment by relaying external inputs via intracellular signaling networks. One central …

Integrin-mediated focal adhesions are the primary architectures that transmit forces between
the extracellular matrix (ECM) and the actin cytoskeleton. Although focal adhesions are …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …

Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an
important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …

Hemidesmosomes are specialized cell-matrix adhesion structures that are associated with
the keratin cytoskeleton. Although the adhesion function of hemidesmosomes has been …

The ability of cells to migrate is a fundamental physiological process involved in embryonic
development, tissue homeostasis, immune surveillance and wound healing. In order for …