Senile plaques induced by β-amyloid (Aβ) abnormal aggregation and neurofibrillary tangles
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …

Glycogen synthase kinase-3β (GSK-3β) is a conserved serine/threonine kinase that
participates in the transmission of multiple signaling pathways and plays an important role in …

Poor pharmacokinetic and safety profiles create significant hurdles in the drug development
process. This work focuses on a detailed understanding of drug discovery interplay among …

Tumors are still one of the main causes of death; therefore, the search for new therapeutic
agents that will enable the implementation of effective treatment is a significant challenge for …

Background Insufficient solubility and stability of bioactive small molecules as well as poor
biocompatibility may cause low bioavailability and are common obstacles in drug …

Oxindole is a nature-derived heteroaromatic nucleus with a history of preclinical uses in
various conditions. In this study, oxindole derivatives, 6-chloro-3-(3-hydroxybenzylidene) …

Carboplatin and the closely associated Cisplatin functioning as antitumor agents are among
the main platinum-based drugs with wide application in treating various types of cancer. It …

Ишемическая болезнь сердца, острый коронарный синдром, ишемический инсульт,
нарушение периферического кровообращения в конечностях, осложнения сахарного …