Liver X receptors in lipid metabolism: opportunities for drug discovery

C Hong, P Tontonoz - Nature reviews Drug discovery, 2014 - nature.com
The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Vitamin D in plants: a review of occurrence, analysis, and biosynthesis

RB Jäpelt, J Jakobsen - Frontiers in plant science, 2013 - frontiersin.org
The major function of vitamin D in vertebrates is maintenance of calcium homeostasis, but
vitamin D insufficiency has also been linked to an increased risk of hypertension …

Malformation syndromes caused by disorders of cholesterol synthesis

FD Porter, GE Herman - Journal of lipid research, 2011 - ASBMB
Cholesterol homeostasis is critical for normal growth and development. In addition to being
a major membrane lipid, cholesterol has multiple biological functions. These roles include …

Zebrafish embryonic lipidomic analysis reveals that the yolk cell is metabolically active in processing lipid

D Fraher, A Sanigorski, NA Mellett, PJ Meikle… - Cell reports, 2016 - cell.com
The role of lipids in providing energy and structural cellular components during vertebrate
development is poorly understood. To elucidate these roles further, we visualized lipid …

Sterol side chain reductase 2 is a key enzyme in the biosynthesis of cholesterol, the common precursor of toxic steroidal glycoalkaloids in potato

S Sawai, K Ohyama, S Yasumoto, H Seki… - The Plant …, 2014 - academic.oup.com
Potatoes (Solanum tuberosum) contain α-solanine and α-chaconine, two well-known toxic
steroidal glycoalkaloids (SGAs). Sprouts and green tubers accumulate especially high levels …

[图书][B] Handbook of vitamins

J Zempleni, JW Suttie, JF Gregory III, PJ Stover - 2013 - books.google.com
Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

[HTML][HTML] Lipoproteins, cholesterol homeostasis and cardiac health

TF Daniels, KM Killinger, JJ Michal… - … journal of biological …, 2009 - ncbi.nlm.nih.gov
Cholesterol is an essential substance involved in many functions, such as maintaining cell
membranes, manufacturing vitamin D on surface of the skin, producing hormones, and …

Cholesterol–the devil you know; ceramide–the devil you don't

TS Tippetts, WL Holland, SA Summers - Trends in pharmacological …, 2021 - cell.com
Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …

Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies

B Roskams-Hieter, HJ Kim, P Anur, JT Wagner… - NPJ Precision …, 2022 - nature.com
Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

RB Corcoran, MP Scott - Proceedings of the national …, 2006 - National Acad Sciences
Sterol synthesis is required for Sonic hedgehog (Shh) signal transduction. Errors in Shh
signal transduction play important roles in the formation of human tumors, including …