Tobacco smoking is a leading cause of non-communicable disease globally and is a major
risk factor for cardiovascular disease (CVD) and lung disease. Importantly, recent data by …

Introduction There is an increasing interest in understanding whether air pollutants modify
the quantitative relationships between temperature and health outcomes. The results of …

Emerging evidence indicates that l-glutamine (Gln) plays a fundamental role in
cardiovascular physiology and pathology. By serving as a substrate for the synthesis of …

Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of
gas therapy as it shows the promise of treating various diseases. Due to the gaseous …

Oxygen and carbon dioxide are time honored gases that have direct bearing on almost all
life forms, but over the past thirty years, and in large part due to the Nobel Prize Award in …

Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative
conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is …

Cardiovascular functionality strictly depends on endothelial cell trophism and proper
biochemical function. Any condition (environmental, pharmacological/toxicological, physical …

Along with the impressive achievements in understanding the endogenous signaling roles
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …

Nature has endowed gaseous molecules such as O 2, CO 2, CO, NO, H 2 S, and N 2 with
critical and diverse roles in sustaining life, from supplying energy needed to power life and …

Treating acute kidney injury (AKI) represents an important unmet medical need both in terms
of the seriousness of this medical problem and the number of patients. There is also a large …