Antimicrobial diterpenes: Recent development from natural sources

P Saha, FI Rahman, F Hussain… - Frontiers in …, 2022 - frontiersin.org
Antimicrobial resistance has been posing an alarming threat to the treatment of infectious
diseases over the years. Ineffectiveness of the currently available synthetic and …

Abietane‐Type Diterpenoids: Insights into Structural Diversity and Therapeutic Potential

Z Sargazifar, D Ghorbanian Charami… - Chemistry & …, 2024 - Wiley Online Library
The abietane‐type diterpenoids are among the most significant diterpene subsets found in
hundreds of plant species belonging to various families. Among which, the members of the …

Antimicrobial Activity and Molecular Docking Studies of the Biotransformation of Diterpene Acanthoic Acid Using the Fungus Xylaria sp.

AMR Marinho, CMSC de Oliveira, JV Silva-Silva… - Antibiotics, 2023 - mdpi.com
Biotransformations are reactions mediated by microorganisms, such as fungi. These
bioreactions have high chemo-and stereoselectivity on organic substrates and can be …

New diterpenes with potential antitumoral activity isolated from plants in the years 2017–2022

C Forzato, P Nitti - Plants, 2022 - mdpi.com
Diterpenes represent a wider class of isoprenoids, with more than 18,000 isolated
compounds, and are present in plants, fungi, bacteria, and animals in both terrestrial and …

Bioprospecting and bioassay-guided isolation of medicinal plants—A tool for drug discovery

CL Zhao, WI Chik, HJ Zhang - Evidence-Based Validation of Herbal …, 2022 - Elsevier
Medicinal plants have been serving as vital sources for drug discovery. A significant
proportion of clinically approved drugs are originated from plant-derived natural products …

Abietane diterpenoids from Isodon amethystoides and their biological activities

L Zhou, CL Zhao, CY Xu, MH Dong, JH Ye, JJ Zhang… - Phytochemistry, 2024 - Elsevier
Seven undescribed abietane diterpenoids [abietamethinols AG (1-7)] were isolated from the
twigs and leaves of Isodon amethystoides. Their structures were elucidated on the basis of …

Semisynthesis and Cytotoxic Activities of Novel Oxime Ester Derivatives of the Diterpene Stemodin

JAC Oliveira, CJ Alves Filho, AMA Lima… - Journal of the Brazilian …, 2024 - SciELO Brasil
Stemodin (1) is a diterpene produced by Stemodia maritima L.(Scrophulariaceae) and
shows antiviral and tumor cell proliferation inhibitory activities. Chemical modifications of 1 …

Bioactive icetexane and abietane diterpenes from Isodon phyllopodus

R Deng, J Zou, CL Zhao, YM Yang, CF Ku… - Natural Product …, 2023 - Taylor & Francis
Abstract A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-
triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17 …

Design, Synthesis and Biological Evaluation of Lophanic Acid Derivatives as Antifungal and Antibacterial Agents

X Yu, X Song, Y Zhang, Y Yang, J Ye, Y Liu, L Pan… - Molecules, 2022 - mdpi.com
In order to discover more promising antifungal and antibacterial agents, a series of new
derivatives were designed and synthesized by structure modification based on the naturally …

Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities

Y Zang, R Sun, R Feng, H Zhu… - Chinese Journal of …, 2025 - Wiley Online Library
Comprehensive Summary Terpenoids are a large and diverse family of secondary
metabolites that have gained more attention from chemists and pharmacologists for their …