Microtubule-mediated transport of macromolecules and organelles (also known as" cargo")
is essential for cells to function. Deficiencies in cytoplasmic transport are frequently …

The past decade has seen an unprecedented data explosion in biology. It has become
evident that in order to take full advantage of the potential wealth of information hidden in the …

This paper presents a computationally efficient, two-dimensional, feature point tracking
algorithm for the automated detection and quantitative analysis of particle trajectories as …

Cell migration initiates by extension of the actin cytoskeleton at the leading edge.
Computational analysis of fluorescent speckle microscopy movies of migrating epithelial …

Cells exhibit a biphasic migration-velocity response to increasing adhesion strength, with
fast migration occurring at intermediate extracellular matrix (ECM) concentration and slow …

We introduce a new extension of image correlation spectroscopy (ICS) and image cross-
correlation spectroscopy (ICCS) that relies on complete analysis of both the temporal and …

Cell migration is a highly coordinated process involving a multitude of separable but
intertwined phenomena traditionally studied in multiple cell types, tissues and model …

Integrins are transmembrane receptors that, upon activation, bind extracellular ligands and
link them to the actin filament (F-actin) cytoskeleton to mediate cell adhesion and migration …

Image correlation microscopy methodology was extended and used to determine
retrospectively the density, dynamics and interactions of α5-integrin in migrating cells. α5 …

The actin cytoskeleton is locally regulated for functional specializations for cell motility.
Using quantitative fluorescent speckle microscopy (qFSM) of migrating epithelial cells, we …