Oroxylin A: A promising flavonoid for prevention and treatment of chronic diseases

A Sajeev, M Hegde, S Girisa, TN Devanarayanan… - Biomolecules, 2022 - mdpi.com
There have been magnificent advancements in the understanding of molecular mechanisms
of chronic diseases over the past several years, but these diseases continue to be a …

Modulation of diverse oncogenic signaling pathways by oroxylin A: An important strategy for both cancer prevention and treatment

A Sajeev, M Hegde, UD Daimary, A Kumar, S Girisa… - Phytomedicine, 2022 - Elsevier
Background Regardless of major advances in diagnosis, prevention and treatment
strategies, cancer is still a foreboding cause due to factors like chemoresistance …

De Novo Production of Plant 4′-Deoxyflavones Baicalein and Oroxylin A from Ethanol in Crabtree-Negative Yeast

Z Qian, J Yu, X Chen, Y Kang, Y Ren, Q Liu… - ACS Synthetic …, 2022 - ACS Publications
Baicalein and oroxylin A are well-known medicinal 4′-deoxyflavones found mainly in the
roots of traditional medicinal plant Scutellaria baicalensis Georgi. However, extraction from …

Nanomedicine Strategies for Targeting Tumor Stroma

MC Su, SK Nethi, PK Dhanyamraju, S Prabha - Cancers, 2023 - mdpi.com
Simple Summary The tumor microenvironment plays an important role in drug resistance
and supports/promotes tumorigenesis. Stromal modulators in combination with …

Cellular and molecular mechanisms of oroxylin A in cancer therapy: Recent advances

PX Wang, XN Mu, SH Huang, K Hu, ZG Sun - European Journal of …, 2024 - Elsevier
Seeking an effective and safe scheme is the common goal of clinical treatment of tumor
patients. In recent years, traditional Chinese medicine has attracted more and more attention …

CAM-DR: Mechanisms, roles and clinical application in tumors

Y Huang, Y Wang, J Tang, S Qin, X Shen… - Frontiers in Cell and …, 2021 - frontiersin.org
Despite the continuous improvement of various therapeutic techniques, the overall
prognosis of tumors has been significantly improved, but malignant tumors in the middle and …

Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway

Q Song, L Lin, Y Chen, J Qian, K Wei, J Su… - Acta Pharmacologica …, 2023 - nature.com
Malignant glioma is the most fatal, invasive brain cancer with limited treatment options. Our
previous studies show that 2-(indol-3-ylmethyl)-3, 3′-diindolylmethane (LTr1), a major …

Vimentin loss promotes cancer proliferation through up-regulating Rictor/AKT/β-catenin signaling pathway

Y Ding, C Lv, Y Zhou, H Zhang, L Zhao, Y Xu… - Experimental Cell …, 2021 - Elsevier
Vimentin protein is one of the main cytoskeleton and plays an important role in cell motility
and metastasis. Nowadays, vimentin is widely studied as an epithelial-mesenchymal …

Anticancer potential of oroxylin A: from mechanistic insight to synergistic perspectives

HS Tuli, VK Garg, A Kumar, D Aggarwal… - Naunyn-Schmiedeberg's …, 2023 - Springer
Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in
ethnomedicine already for centuries in treating various neoplastic disorders. However, only …

Programmable Biosynthesis of Plant‐Derived 4′‐Deoxyflavone Glycosides by an Unconventional Yeast Consortium

Y Kang, Z Qian, H Yu, J Lu, Q Zhao, X Qiao… - Small …, 2024 - Wiley Online Library
Previous data established 4′‐deoxyflavone glycosides (4′‐DFGs) as important
pharmaceutical components in the roots of rare medical plants like Scutellaria baicalensis …