The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …

▪ Abstract Regulation of tyrosine phosphorylation is a critical control point for integration of
environmental signals into cellular responses. This regulation is mediated by the reciprocal …

Background The mutational status of immunoglobulin heavy-chain variable-region (IgVH)
genes in the leukemic cells of chronic lymphocytic leukemia (CLL) is an important prognostic …

The function of the Src-family kinases (SFKs) Lck and Fyn in T cells has been intensively
studied over the past 15 years. Animal models and cell line studies both indicate a critical …

Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …

Psoriasis is a chronic inflammatory disorder of the skin that is mediated by T cells, dendritic
cells and inflammatory cytokines. We now understand many of the cellular alterations that …

We have designed and synthesized a new hydrogelator Nap− FFGEY (1), which forms a
supramolecular hydrogel. A kinase/phosphatase switch is used to control the …

The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and
versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target …

Current evidence highlights the ability of adaptor (or scaffold) proteins to create signalling
platforms that drive cellular transformation upon integrin-dependent adhesion and growth …

Integrins regulate cell adhesion and motility through tyrosine kinases, but initiation of this
process is poorly understood. We find here that Src associates constitutively with integrin …